The crash involved a motorcyclist and a semitrailer, state police said.
It took place just before 11:15 a.m. on southbound I-294 near mile marker 26.75 in Western Springs, police said.
Officials did not immediately provide additional information about what led up to the deadly crash.
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The right two lanes were closed for hours, police said.
Chopper7 was over the scene about 12:15 p.m., and there was a large traffic backup in the area.
The lanes reopened around 4:30 p.m.